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Research Associate I/II I-O

L5

systimmuneBothell, WAtoday

Occupations

Medical Scientists, Except EpidemiologistsMolecular and Cellular BiologistsBiological Technicians

Industries

Research and Development in BiotechnologyResearch and Development in the Physical, Engineering, and Life SciencesBiological Product Manufacturing
Research Associate I/IISystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials, SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. SystImmune Inc. is seeking a motivated Research Associate I/II to join the Bioassay team within the Immuno-Oncology department. This role will support the engineering of complex cell lines and the execution of cell-based immunoassays to enable the discovery and development of novel cancer therapeutics. The ideal candidate will be a strong experimentalist with direct experience in genetic modification (such as lentiviral transduction and knock-in/out) and bioassay execution who thrives in a fast-paced, collaborative environment. This is a hands-on laboratory role focused on critical materials generation, assay execution, and data analysis. The successful candidate will maintain high-quality experimental standards while developing deep technical expertise in immuno-oncology drug development. This role is full-time onsite in Redmond, WA and will move to Bothell, WA fall 2026.
Key Responsibilities:
  • Engineer stable cell lines using lentiviral transduction, CRISPR knock-ins, and knock-outs
  • Analyze complex datasets, prepare technical reports, and present findings to internal teams.
  • Perform rigorous batch qualification of critical reagents and cell lines to ensure assay consistency.
  • Maintain and manipulate complex co-cultures of primary immune cells and engineered cancer cell lines.
  • Conduct functional assays using Incucyte live-cell imaging, flow cytometry, and ELISA-based platforms.
  • Develop, optimize, and validate cell-based and immunoassays to support drug development programs.
Qualifications:
  • Research Associate I:BS or MS in Biology, Immunology, Cell Biology, Bioengineering, Biochemistry, or related scientific field
  • Minimum 1+ year of industry laboratory experience (internships may be considered if highly relevant)
  • Hands-on experience with mammalian cell culture techniques and aseptic techniques
  • Exposure to genetic modification workflows such as transient transfections or lentiviral transduction
  • Basic familiarity executing immunoassays such as ELISA or flow cytometry
  • Strong organizational skills and attention to detail
  • Ability to work effectively in a team environment
  • Research Associate II:BS or MS in a relevant scientific discipline
  • Typically, 2–4 years of relevant industry experience
  • Direct experience engineering cell lines, including executing lentiviral transductions and knock-ins
  • Proven track record executing and troubleshooting cell-based assays and flow cytometry workflows
  • Demonstrated ability to work with moderate independence
Preferred Qualifications: Experience supporting oncology, immuno-oncology, immunology, or biologics drug discovery programs. Experience with single-cell cloning, CRISPR/Cas9 workflows, or stable cell line selection. Proficiency with Incucyte live-cell imaging, multi-color flow cytometry, or MSD multiplex platforms. Exposure to high-throughput research settings or regulated laboratory environments. Strong data analysis software skills (e.g., GraphPad Prism, FlowJo) and scientific communication skills
Compensation and Benefits: The expected base salary range for this position is 60,000 - 80,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate's level qualifications, experience, and skills. While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role. SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.
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Level

SeniorL5

Location

Bothell, WA

Occupation

Medical Scientists, Except Epidemiologists

Industry

Research and Development in Biotechnology

Posted

today

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