Principal Scientist – Fluorophore Chemistry & CMC

What you'll do: Design and synthesise novel fluorophores, with an emphasis on polymethine and near-infrared dyes Develop and optimise multistep synthetic routes, troubleshooting them from first principles Take molecules from bench through scale-up to GMP manufacture Act as the technical interface to the CMC provider: specifications, impurity control, batch records, campaign oversight Support IND-stage CMC documentation Work alongside the peptide and organic chemistry team on conjugation and bioconjugate chemistry

What you'll need: PhD in Organic Chemistry or a closely related field Demonstrable hands-on fluorophore synthesis: dyes you have made yourself, not purchased and conjugated GMP experience and working knowledge of the CMC section of a drug application Track record taking chemistry from laboratory scale to GMP manufacture Click chemistry and bioconjugation Excellent safety record with organic solvents, oxidising agents and flammables Someone who reasons past a failed reaction rather than stopping at "it doesn't work"