Senior Scientist, Bioanalytical Sciences

Key responsibilities include: Design, develop and execute cell-based immunoassays, flow cytometry based assays and LBAs to assess immunogenicity to LNP delivered nucleic acid cargoes in vitro and in vivo Apply knowledge of innate immunology and establish in vitro screening assays for various nucleic acid modalities and establish criteria for release of cargo for pre-clinical research Collaborate closely with CMC, molecular biology and cell biology teams to screen nucleic acid cargoes (immunogenicity assessment etc.) and ensure timely delivery of high-quality data and summarize results Ensure development, qualification, and validation of bioanalytical assays in compliance with applicable guidelines Design, optimize, and execute biodistribution studies (flow cytometry and histological techniques) for LNP/nucleic acid therapies Design, establish and execute assays for assessing various in vivo immunogenicity predictors for LNP/nucleic acid therapies including but not limited to biomarkers, cytokines, complement activation and anti-drug antibodies (ADA) in rodents and NHPsDesign, develop, optimize, and execute bioanalytical assays to support nonclinical studies, including PK, PD, biomarker, and immunogenicity endpoints Execute test procedures such as sample extraction and measurement by Flow Cytometry, ELISA, MSD, Luminex, bDNA, ddPCR and perform data interpretation Analyze and summarize scientific data and maintain timely documentation and completion of electronic lab notebooks in compliance with industry guidelines Present at project team meetings and to relevant stakeholders Mentor, coach, and manage junior scientists