(Senior) Scientist, Translational Biology

Key Responsibilities: Design, execute, and analyze complex in vitro / in vivo experiments to support research programs Lead and perform multi-parameter flow cytometry assays, including panel design, optimization, and data interpretation Perform and optimize primary cell isolation from tissues, including enzymatic and mechanical tissue dissociation, magnetic-activated cell sorting (MACS), and fluorescence-activated cell sorting (FACS), with attention to preserving cell viability, yield, native gene-expression signatures, and potential for further culture of the cells Perform and interpret microscopy-based assays, including high-content microscopy, immunofluorescence, confocal, and/or intravital imaging, to characterize cell and tissue phenotypes and validate target engagement Support mouse studies as needed, including disease models, dosing, tissue collection, and phenotypic analysis Develop and apply siRNA-based approaches for target validation and mechanistic studies Analyze and interpret data, generate reports, and present findings to cross-functional teams Collaborate with internal and external stakeholders to advance project goals Mentor junior scientists and contribute to a collaborative team environment Maintain accurate experimental records and ensure compliance with institutional and regulatory guidelines

Qualifications: Ph. D. in Molecular Biology, Cell Biology, or a related field with 3–6+ years of relevant experience (industry preferred), or M.S. with significant experience Strong expertise in flow cytometry, including cell sorting (FACS), panel design, troubleshooting, and data analysis (e.g., FlowJo or similar tools) Hands-on experience with primary cell isolation techniques from mouse tissue, including tissue dissociation (enzymatic and mechanical), magnetic bead-based separation (MACS), and isolation of rare or fragile cell populations Hands-on experience with microscopy techniques (e.g., immunofluorescence, confocal microscopy) and associated image analysis software (e.g., ImageJ/Fiji, Imaris, or similar) Demonstrated experience with siRNA design, delivery, and functional validation Strong data analysis and problem-solving skills Excellent communication and presentation skills Ability to work independently and collaboratively in a fast-paced environment